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Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR, Hanahan D
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.
Genes & development , Sep-15-2009;23(18):2152-65.
Satpathy M, Shao M, Emerson R, Donner DB, Matei D
Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity.
The Journal of biological chemistry , Jun-5-2009;284(23):15390-9. Epub 2009 Mar 26.
Bertagnolli MM, Niedzwiecki D, Compton CC, Hahn HP, Hall M, Damas B, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Warren RS, Redston M
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology , Apr-10-2009;27(11):1814-21. Epub 2009 Mar 9.
Bertagnolli MM, Warren RS, Niedzwiecki D, Mueller E, Compton CC, Redston M, Hall M, Hahn HP, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Loda M
p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.
Clinical cancer research : an official journal of the American Association for Cancer Research , Mar-15-2009;15(6):2116-22. Epub 2009 Mar 10.
Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK
Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
Endocrine-related cancer , Mar-2009;16(1):267-79. Epub 2008 Nov 5.
Pincheira R, Baerwald M, Dunbar JD, Donner DB
Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth.
The EMBO journal , Feb-4-2009;28(3):261-73. Epub 2009 Jan 08.
Ruan DT, Warren RS, Moalem J, Chung KW, Griffin AC, Shen W, Duh QY, Nakakura E, Donner DB, Khanafshar E, Weng J, Clark OH, Kebebew E
Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers.
Surgery , Dec-2008;144(6):908-13; discussion 913-4.
Pincheira R, Donner DB
The Sall2 transcription factor is a novel p75NTR binding protein that promotes the development and function of neurons.
Annals of the New York Academy of Sciences , Nov-2008;1144:53-5.
Pincheira R, Castro AF, Ozes ON, Idumalla PS, Donner DB
Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity.
Journal of immunology (Baltimore, Md. : 1950) , Jul-15-2008;181(2):1288-98.
Chan JA, Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Thomas J, Schaefer P, Whittom R, Hantel A, Goldberg RM, Warren RS, Bertagnolli M, Fuchs CS
Association of family history with cancer recurrence and survival among patients with stage III colon cancer.
JAMA : the journal of the American Medical Association , Jun-4-2008;299(21):2515-23.
Horvai AE, Schaefer JT, Nakakura EK, O'Donnell RJ
Immunostaining for peroxisome proliferator gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc , May-2008;21(5):517-24. Epub 2008 Jan 18.
LaRusch GA, Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD
Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.
Cancer research , Jan-15-2007;67(2):450-4.
Matei D, Satpathy M, Cao L, Lai YC, Nakshatri H, Donner DB
The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.
The Journal of biological chemistry , Jan-5-2007;282(1):445-53. Epub 2006 Nov 1.
Korn WM, Macal M, Christian C, Lacher MD, McMillan A, Rauen KA, Warren RS, Ferrell L
Expression of the coxsackievirus- and adenovirus receptor in gastrointestinal cancer correlates with tumor differentiation.
Cancer gene therapy , Aug-2006;13(8):792-7. Epub 2006 Apr 21.
Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.
Cancer research , Aug-1-2006;66(15):7509-15.
Gustin JA, Korgaonkar CK, Pincheira R, Li Q, Donner DB
Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52.
The Journal of biological chemistry , Jun-16-2006;281(24):16473-81. Epub 2006 Apr 12.
Jackson MW, Patt LE, LaRusch GA, Donner DB, Stark GR, Mayo LD
Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells.
The Journal of biological chemistry , Jun-16-2006;281(24):16814-20. Epub 2006 Apr 18.
Schmidt NW, Mayo LD, Donner DB, Kaplan MH
p53 regulates Btk-dependent B cell proliferation but not differentiation.
Journal of leukocyte biology , Apr-2006;79(4):852-9. Epub 2006 Feb 3.
Matei D, Emerson RE, Lai YC, Baldridge LA, Rao J, Yiannoutsos C, Donner DD
Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer.
Oncogene , Mar-30-2006;25(14):2060-9.
Srirangam A, Mitra R, Wang M, Gorski JC, Badve S, Baldridge L, Hamilton J, Kishimoto H, Hawes J, Li L, Orschell CM, Srour EF, Blum JS, Donner D, Sledge GW, Nakshatri H, Potter DA
Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research , Mar-15-2006;12(6):1883-96.
Mayo LD, Seo YR, Jackson MW, Smith ML, Rivera Guzman J, Korgaonkar CK, Donner DB
Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.
The Journal of biological chemistry , Jul-15-2005;280(28):25953-9. Epub 2005 Apr 20.
Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW
Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.
The Journal of clinical endocrinology and metabolism , Jul-2005;90(7):4350-6. Epub 2005 May 3.
Arvold ND, Guha N, Wang D, Matli M, Deen DF, Warren RS, Haas-Kogan DA
Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro.
International journal of radiation oncology, biology, physics , May-1-2005;62(1):207-12.
Mehta KR, Nakao K, Zuraek MB, Ruan DT, Bergsland EK, Venook AP, Moore DH, Tokuyasu TA, Jain AN, Warren RS, Terdiman JP, Waldman FM
Fractional genomic alteration detected by array-based comparative genomic hybridization independently predicts survival after hepatic resection for metastatic colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research , Mar-1-2005;11(5):1791-7.
Toussaint-Smith E, Donner DB, Roman A
Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors.
Oncogene , Apr-15-2004;23(17):2988-95.
Gustin JA, Pincheira R, Mayo LD, Ozes ON, Kessler KM, Baerwald MR, Korgaonkar CK, Donner DB
Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells.
American journal of physiology. Cell physiology , Mar-2004;286(3):C547-55.
Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo LD, Li Q, Guzman JR, Korgaonkar CK, Donner DB
Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation.
The Journal of biological chemistry , Jan-16-2004;279(3):1615-20.
Su JD, Mayo LD, Donner DB, Durden DL
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.
Cancer research , Jul-1-2003;63(13):3585-92.
Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, Wiesmann M, Garcia PD, Fuller JH, Chan V, Randazzo F, Gundel R, Warren RS, Escobedo J, Aukerman SL, Taylor RN, Fantl WJ
beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
Cancer research , Jun-15-2003;63(12):3145-53.
Mayo LD, Donner DB
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network.
Trends in biochemical sciences , Sep-2002;27(9):462-7.
Warren RS, Kirn DH
Liver-directed viral therapy for cancer p53-targeted adenoviruses and beyond.
Surgical oncology clinics of North America , Jul-2002;11(3):571-88, vi.
Wang D, Lehman RE, Donner DB, Matli MR, Warren RS, Welton ML
Expression and endocytosis of VEGF and its receptors in human colonic vascular endothelial cells.
American journal of physiology. Gastrointestinal and liver physiology , Jun-2002;282(6):G1088-96.
Sriuranpong V, Borges MW, Strock CL, Nakakura EK, Watkins DN, Blaumueller CM, Nelkin BD, Ball DW
Notch signaling induces rapid degradation of achaete-scute homolog 1.
Molecular and cellular biology , May-2002;22(9):3129-39.
Mayo LD, Dixon JE, Durden DL, Tonks NK, Donner DB
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.
The Journal of biological chemistry , Feb-15-2002;277(7):5484-9.
Nakakura EK, Watkins DN, Sriuranpong V, Borges MW, Nelkin BD, Ball DW
Mammalian Scratch participates in neuronal differentiation in P19 embryonal carcinoma cells.
Brain research. Molecular brain research , Nov-1-2001;95(1-2):162-6.
Mayo LD, Donner DB
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
Proceedings of the National Academy of Sciences of the United States of America , Sep-25-2001;98(20):11598-603.
Gustin JA, Maehama T, Dixon JE, Donner DB
The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity.
The Journal of biological chemistry , Jul-20-2001;276(29):27740-4.
Mayo LD, Kessler KM, Pincheira R, Warren RS, Donner DB
Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase.
The Journal of biological chemistry , Jul-6-2001;276(27):25184-9.
Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB, Pfeffer LM
Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt.
The Journal of biological chemistry , Apr-27-2001;276(17):13756-61.
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Proceedings of the National Academy of Sciences of the United States of America , Apr-10-2001;98(8):4640-5.
Nakakura EK, Watkins DN, Schuebel KE, Sriuranpong V, Borges MW, Nelkin BD, Ball DW
Mammalian Scratch: a neural-specific Snail family transcriptional repressor.
Proceedings of the National Academy of Sciences of the United States of America , Mar-27-2001;98(7):4010-5.
Godfrey TE, Kim SH, Chavira M, Ruff DW, Warren RS, Gray JW, Jensen RH
Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5' nuclease quantitative reverse transcription-polymerase chain reaction.
The Journal of molecular diagnostics : JMD , May-2000;2(2):84-91.
Guo DQ, Wu LW, Dunbar JD, Ozes ON, Mayo LD, Kessler KM, Gustin JA, Baerwald MR, Jaffe EA, Warren RS, Donner DB
Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell proliferation.
The Journal of biological chemistry , Apr-14-2000;275(15):11216-21.
Wu LW, Mayo LD, Dunbar JD, Kessler KM, Ozes ON, Warren RS, Donner DB
VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.
The Journal of biological chemistry , Mar-3-2000;275(9):6059-62.
Wu LW, Mayo LD, Dunbar JD, Kessler KM, Ozes ON, Warren RS, Donner DB
VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.
The Journal of biological chemistry , Mar-3-2000;275(9):6059-62.
Wu LW, Mayo LD, Dunbar JD, Kessler KM, Baerwald MR, Jaffe EA, Wang D, Warren RS, Donner DB
Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation.
The Journal of biological chemistry , Feb-18-2000;275(7):5096-103.
Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.
The Journal of biological chemistry , Feb-4-2000;275(5):3305-12.
Pazdernik NJ, Donner DB, Goebl MG, Harrington MA
Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB.
Molecular and cellular biology , Oct-1999;19(10):6500-8.
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.
Nature , Sep-2-1999;401(6748):82-5.
Korn WM, Yasutake T, Kuo WL, Warren RS, Collins C, Tomita M, Gray J, Waldman FM
Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization.
Genes, chromosomes & cancer , Jun-1999;25(2):82-90.
Vig E, Green M, Liu Y, Donner DB, Mukaida N, Goebl MG, Harrington MA
Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaB activity by mPLK/IRAK.
The Journal of biological chemistry , May-7-1999;274(19):13077-84.
Wu LW, Reid S, Ritchie A, Broxmeyer HE, Donner DB
The proteasome regulates caspase-dependent and caspase-independent protease cascades during apoptosis of MO7e hematopoietic progenitor cells.
Blood cells, molecules & diseases , Feb-1999;25(1):20-9.
Ankoma-Sey V, Matli M, Chang KB, Lalazar A, Donner DB, Wong L, Warren RS, Friedman SL
Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing.
Oncogene , Jul-9-1998;17(1):115-21.
Xie J, Johnson RL, Zhang X, Bare JW, Waldman FM, Cogen PH, Menon AG, Warren RS, Chen LC, Scott MP, Epstein EH
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.
Cancer research , Jun-15-1997;57(12):2369-72.
Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB
Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma.
The Journal of biological chemistry , Nov-15-1996;271(46):29483-8.